Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 16/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 16/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6822670 | 1.00 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4030234 | 0.89 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4030231 | 0.89 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4027814 | 0.79 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4025227 | 0.76 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4025224 | 0.76 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4027365 | 0.74 | PDE4A (0.90) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4027369 | 0.74 | PDE4A (0.90) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4028925 | 0.74 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4031232 | 0.74 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6740666-B2 | FOR THERAPY OF ASTHMA, CHRONIC BRONCHITIS, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, EOSINOPHILIC GRANULOMA, PSORIASIS; SEPTIC SHOCK, ULCERATIVE COLITIS, CROHN'S DISEASE, REPERFUSION INJURY OF THE MYOCARDIUM AND BRAIN, INFLAMMATION | MERCK & CO., INC. | 2004-05-25 | — | — | US | disclosed |