Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.62 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.44 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 8/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 7/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38942 | 0.80 | HRH4 (0.85) | HRH4PDPK1GDAMAP3K5CDK2 | |
| Hydrochloric Acid SCHEMBL7290518 | 0.80 | HRH4 (0.70) | HRH4PDPK1GDAMAP3K5CDK2 | |
| SCHEMBL16178571 | 0.71 | PI4KB (0.48) | HRH4 | |
| SCHEMBL27201438 | 0.70 | MAP4K4 (0.51) | HRH4PDPK1GDAMAP3K5CDK2 | |
| SCHEMBL30834277 | 0.70 | MAP4K4 (0.51) | HRH4PDPK1GDAMAP3K5CDK2 | |
| SCHEMBL1775193 | 0.69 | HRH4 (0.44) | HRH4KIT | |
| SCHEMBL1773848 | 0.69 | HRH4 (0.44) | HRH4KIT | |
| SCHEMBL1774270 | 0.69 | HRH4 (0.44) | HRH4KIT | |
| SCHEMBL603504 | 0.68 | HRH4 (0.43) | HRH4KIT | |
| SCHEMBL1773986 | 0.68 | HRH4 (0.43) | HRH4KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004074287-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-09-02 | — | — | WO | disclosed |