Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDE9A | O76083 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6781971 | 0.93 | MAPK1 (0.52) | MAPK1SMN1; SMN2LMNAMAPTTDP1 | |
| Bicarbonate SCHEMBL6919502 | 0.87 | MAPK1 (0.47) | MAPK1SMN1; SMN2LMNAMAPTTDP1 | |
| Bicarbonate SCHEMBL6919501 | 0.87 | MAPK1 (0.47) | MAPK1SMN1; SMN2LMNAMAPTTDP1 | |
| Bicarbonate SCHEMBL6919500 | 0.86 | MAPK1 (0.47) | MAPK1SMN1; SMN2LMNAMAPTTDP1 | |
| SCHEMBL1531299 | 0.80 | TDP1 (0.57) | MAPK1SMN1; SMN2LMNAMAPTTDP1 | |
| SCHEMBL6824484 | 0.80 | MAPK1 (0.54) | MAPK1SMN1; SMN2LMNAMAPTTDP1 | |
| SCHEMBL6714799 | 0.80 | MAPK1 (0.51) | MAPK1SMN1; SMN2LMNAMAPTTDP1 | |
| SCHEMBL2061097 | 0.78 | CHRNB4 (0.51) | LMNATDP1ALDH1A1KDM4EHIF1A | |
| SCHEMBL4192847 | 0.77 | MAPK1 (0.47) | MAPK1SMN1; SMN2ALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL2813011 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAMAPTTDP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004010943-A2 | SUBSTITUTED BENZANILIDES AS MODULATORS OF THE CCR5 RECEPTOR | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-05 | — | — | WO | disclosed |