Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CFTR | P13569 | 3/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26596782 | 0.86 | CYP46A1 (0.47) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL505337 | 0.85 | KDM4E (0.50) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL5629366 | 0.85 | KDM4E (0.63) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL18829858 | 0.83 | CA12 (0.50) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL28043811 | 0.83 | KDM4E (0.43) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL11071838 | 0.83 | KDM4E (0.49) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL31615975 | 0.82 | KDM4E (0.52) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL6118855 | 0.82 | KDM4E (0.55) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL3575890 | 0.81 | KDM4E (0.47) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL20334144 | 0.81 | KDM4E (0.47) | KDM4EALDH1A1GAAMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3165520-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme Inc (US) | 2017-05-10 | — | — | EP | disclosed |
| WO-2004073612-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO. INC. (US) | 2004-09-02 | — | — | WO | disclosed |