Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.56 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6820181 | 0.95 | KMT2A (0.59) | KMT2AMEN1CXCR2CXCR1TDP1 | |
| SCHEMBL3711422 | 0.88 | CXCR2 (0.67) | KMT2AMEN1CXCR2CXCR1TDP1 | |
| SCHEMBL5594945 | 0.87 | KMT2A (0.65) | KMT2AMEN1CXCR2CXCR1TDP1 | |
| SCHEMBL3706835 | 0.83 | KMT2A (0.74) | KMT2AMEN1CXCR2CXCR1TDP1 | |
| SCHEMBL7490940 | 0.81 | MAPT (0.68) | KMT2AMEN1CXCR2CXCR1TDP1 | |
| SCHEMBL3716989 | 0.80 | CXCR2 (0.64) | KMT2AMEN1CXCR2CXCR1TDP1 | |
| SCHEMBL5605030 | 0.79 | CXCR1 (0.62) | KMT2AMEN1CXCR2CXCR1TDP1 | |
| SCHEMBL31054245 | 0.78 | MAPT (0.80) | KMT2AMEN1CXCR2CXCR1TDP1 | |
| SCHEMBL5987164 | 0.78 | CXCR1 (0.67) | KMT2AMEN1CXCR2CXCR1TDP1 | |
| SCHEMBL29968760 | 0.78 | CXCR1 (0.67) | KMT2AMEN1CXCR2CXCR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |