Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 14/20 | 0.76 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.65 |
| ▸ | HRH1 | P35367 | 1/20 | 0.65 |
| ▸ | SYK | P43405 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 2/20 | 0.62 |
| ▸ | DRD3 | P35462 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1429630 | 0.86 | HRH4 (1.00) | HRH4HRH3HRH1NPC1RAB9A | |
| SCHEMBL603468 | 0.85 | HRH4 (0.69) | HRH4HRH3HRH1SYKDRD2 | |
| SCHEMBL603564 | 0.82 | HRH4 (0.74) | HRH4HRH3HRH1NPC1RAB9A | |
| SCHEMBL12826978 | 0.81 | HRH4 (0.70) | HRH4HRH3HRH1SYK | |
| SCHEMBL5017140 | 0.81 | HRH4 (0.62) | HRH4HRH3HRH1SYKNPC1 | |
| SCHEMBL13174267 | 0.81 | AKR1C3 (0.81) | HRH4HRH3NPC1RAB9ADRD2 | |
| SCHEMBL601515 | 0.80 | HRH4 (1.00) | HRH4HRH3HRH1NPC1RAB9A | |
| SCHEMBL6130834 | 0.80 | HRH4 (1.00) | HRH4HRH3HRH1 | |
| SCHEMBL14650937 | 0.80 | SYK (1.00) | SYK | |
| SCHEMBL9410529 | 0.79 | DRD3 (0.78) | HRH4NPC1RAB9ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004108671-A1 | SUBSTITUTED INDOLES WITH SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SUVEN LIFE SCIENCES LIMITED (IN) | 2004-12-16 | — | — | WO | disclosed |