Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.59 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.59 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | RAB9A | P51151 | 7/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706598 | 0.91 | MEN1 (0.59) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL7488205 | 0.81 | KMT2A (0.48) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL5595104 | 0.80 | CXCR1 (0.80) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL3711422 | 0.76 | CXCR2 (0.67) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL3706835 | 0.75 | KMT2A (0.74) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL5595118 | 0.75 | CXCR2 (0.74) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL5595247 | 0.75 | CXCR1 (0.69) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL5594962 | 0.74 | MEN1 (0.72) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL5595038 | 0.74 | MEN1 (0.74) | MEN1KMT2ACXCR1CXCR2TDP1 | |
| SCHEMBL6921874 | 0.74 | CXCR2 (1.00) | MEN1KMT2ACXCR1CXCR2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |