Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.35 |
| ▸ | PDE8B | O95263 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5320750 | 0.77 | CCNA2 (0.36) | PDE10A | |
| SCHEMBL11443735 | 0.75 | PDE10A (0.39) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL6826203 | 0.73 | DHODH (0.32) | PDE10A | |
| SCHEMBL6826298 | 0.71 | PDE4D (0.32) | PDE4D | |
| SCHEMBL6826154 | 0.71 | PDE10A (0.41) | PDE10APDE8BCHRM3PDE4APDE4B | |
| SCHEMBL6340021 | 0.67 | CNR2 (0.31) | — | |
| SCHEMBL11444512 | 0.67 | PDE10A (0.33) | PDE10A | |
| SCHEMBL6341152 | 0.66 | PDE10A (0.36) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL5321886 | 0.65 | CSNK2A2 (0.35) | CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL6336289 | 0.65 | EDNRB (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004111000-A2 | PIPERIDYL DERIVATIVES AND THEIR USE AS TACHYKININ ANTAGONISTS | ASTELLAS PHARMA INC. (JP) | 2004-12-23 | — | — | WO | disclosed |