Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6493360 | 0.85 | EGFR (0.66) | EGFRERBB2HDAC3ABL1INSR | |
| SCHEMBL6827596 | 0.83 | EGFR (0.82) | EGFRERBB2 | |
| SCHEMBL6496915 | 0.82 | EGFR (0.69) | EGFRERBB2HDAC3ABL1INSR | |
| SCHEMBL6826956 | 0.80 | EGFR (0.83) | EGFRERBB2 | |
| SCHEMBL6487017 | 0.79 | EGFR (0.68) | EGFRERBB2HDAC3ABL1INSR | |
| SCHEMBL6829305 | 0.79 | EGFR (0.57) | EGFRERBB2ERBB4 | |
| SCHEMBL6496763 | 0.79 | EGFR (0.73) | EGFRERBB2 | |
| SCHEMBL6826984 | 0.79 | EGFR (1.00) | EGFRERBB2 | |
| SCHEMBL6483980 | 0.78 | EGFR (0.78) | EGFRERBB2 | |
| SCHEMBL6486121 | 0.78 | EGFR (0.70) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004112714-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-12-29 | — | — | WO | disclosed |