Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 6/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 10/20 | 0.84 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.84 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.64 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | MAOB | P27338 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6827732 | 1.00 | MIF (1.00) | MIFCYP19A1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL6822395 | 0.92 | MIF (0.85) | MIFCYP19A1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL6822394 | 0.92 | MIF (0.85) | MIFCYP19A1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL4226034 | 0.91 | CYP19A1 (1.00) | MIFCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL4226036 | 0.91 | CYP19A1 (1.00) | MIFCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL4226031 | 0.91 | CYP19A1 (1.00) | MIFCYP19A1CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL4222419 | 0.90 | CYP19A1 (0.97) | MIFCYP19A1CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL4222413 | 0.90 | CYP19A1 (0.97) | MIFCYP19A1CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL4231776 | 0.90 | CYP19A1 (0.97) | MIFCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL6827633 | 0.85 | CYP19A1 (1.00) | MIFCYP19A1CYP11B2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028110-B1 | NOVEL DIHYDRONAPHTHALENE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME | DAIICHI SEIYAKU CO (JP) | 2004-04-14 | — | — | EP | disclosed |
| US-6559157-B2 | Excellent 17 alpha - hydroxylase/C17-20-lyase and aromatase inhibiting activity, thromboxan A2 synthesis inhibiting activity, useful as preventive and/or therapeutic agents for various male and female sex hormone dependent diseases | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-05-06 | — | — | US | disclosed |
| EP-1028110-A1 | NOVEL DIHYDRONAPHTHALENE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME | Yukijirushi Nyugyo Kabushiki Kaisha (JP) | 2000-08-16 | — | — | EP | disclosed |