Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847110 | 1.00 | TACR1 (1.00) | TACR1 | |
| SCHEMBL29870363 | 1.00 | TACR1 (1.00) | TACR1 | |
| SCHEMBL2139814 | 1.00 | TACR1 (1.00) | TACR1 | |
| SCHEMBL8790098 | 0.92 | TACR1 (0.84) | TACR1 | |
| SCHEMBL7062350 | 0.87 | TACR1 (0.76) | TACR1 | |
| SCHEMBL7062087 | 0.86 | TACR1 (0.76) | TACR1 | |
| SCHEMBL8504774 | 0.86 | TACR1 (0.75) | TACR1 | |
| SCHEMBL8101033 | 0.85 | TACR1 (0.78) | TACR1 | |
| SCHEMBL9387393 | 0.85 | TACR1 (0.81) | TACR1 | |
| SCHEMBL8203286 | 0.85 | TACR1 (0.81) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1221950-B1 | SYNERGISTIC COMBINATIONS OF AN NK1 RECEPTOR ANTAGONIST AND A GABA STRUCTURAL ANALOG | WARNER LAMBERT CO (US) | 2004-06-16 | — | — | EP | claimed |
| US-20030232787-A1 | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic | DOOLEY DAVID JAMES (US) | 2003-12-18 | — | — | US | claimed |
| EP-1289558-A2 | COMBINATIONS OF AN ENDOTHELIN RECEPTOR ANTAGONIST AND AN ANTIEPILEPTIC COMPOUND HAVING PAIN ALLEVIATING PROPERTIES OR ANALGESIC | WARNER-LAMBERT COMPANY LLC (US) | 2003-03-12 | — | — | EP | claimed |
| WO-2001091736-A2 | COMBINATIONS OF AN ENDOTHELIN RECEPTOR ANTAGONIST AND AN ANTIEPILEPTIC COMPOUND HAVING PAIN ALLEVIATING PROPERTIES OR ANALGESIC | WARNER-LAMBERT COMPANY (US) | 2001-12-06 | — | — | WO | claimed |
| US-5998435-A | ADMINISTERING A CARBAMIC ESTER OF BENZOFIRAN-2-METHYL ESTER | WARNER-LAMBERT COMPANY (US) | 1999-12-07 | — | — | US | claimed |
| EP-0912173-A1 | USE OF A TACHYKININ ANTAGONIST FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF EMESIS | WARNER-LAMBERT COMPANY (US) | 1999-05-06 | — | — | EP | claimed |
| WO-1997049393-A1 | USE OF A TACHYKININ ANTAGONIST FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF EMESIS | WARNER-LAMBERT COMPANY (US) | 1997-12-31 | — | — | WO | claimed |
| EP-1221950-B1 | SYNERGISTIC COMBINATIONS OF AN NK1 RECEPTOR ANTAGONIST AND A GABA STRUCTURAL ANALOG | WARNER LAMBERT CO (US) | 2004-06-16 | — | — | EP | disclosed |
| US-20030232787-A1 | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic | DOOLEY DAVID JAMES (US) | 2003-12-18 | — | — | US | disclosed |
| EP-1289558-A2 | COMBINATIONS OF AN ENDOTHELIN RECEPTOR ANTAGONIST AND AN ANTIEPILEPTIC COMPOUND HAVING PAIN ALLEVIATING PROPERTIES OR ANALGESIC | WARNER-LAMBERT COMPANY LLC (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001024792-A9 | SYNERGISTIC COMBINATIONS OF AN NK1 RECEPTOR ANTAGONIST AND A GABA STRUCTURAL ANALOG | WARNER LAMBERT CO (US) | 2002-09-06 | — | — | WO | disclosed |
| EP-1233766-A1 | USE OF SYNERGISTIC COMBINATIONS OF A NK 1? RECEPTOR ANTAGONIST AND A GABA ANALOG IN PSYCHIATRIC DISORDERS | WARNER-LAMBERT COMPANY (US) | 2002-08-28 | — | — | EP | disclosed |
| EP-1221950-A1 | SYNERGISTIC COMBINATIONS OF AN NK 1? RECEPTOR ANTAGONIST AND A GABA STRUCTURAL ANALOG | WARNER-LAMBERT COMPANY (US) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001024791-A1 | USE OF SYNERGISTIC COMBINATIONS OF A NK1 RECEPTOR ANTAGONIST AND A GABA ANALOG IN PSYCHIATRIC DISORDERS | WARNER-LAMBERT COMPANY (US) | 2001-04-12 | — | — | WO | disclosed |
| WO-2001024792-A1 | SYNERGISTIC COMBINATIONS OF AN NK1 RECEPTOR ANTAGONIST AND A GABA STRUCTURAL ANALOG | WARNER-LAMBERT COMPANY (US) | 2001-04-12 | — | — | WO | disclosed |
| US-5998435-A | ADMINISTERING A CARBAMIC ESTER OF BENZOFIRAN-2-METHYL ESTER | WARNER-LAMBERT COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0912173-A1 | USE OF A TACHYKININ ANTAGONIST FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF EMESIS | WARNER-LAMBERT COMPANY (US) | 1999-05-06 | — | — | EP | disclosed |
| EP-0912173-A1 | USE OF A TACHYKININ ANTAGONIST FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF EMESIS | WARNER-LAMBERT COMPANY (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997049393-A1 | USE OF A TACHYKININ ANTAGONIST FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF EMESIS | WARNER-LAMBERT COMPANY (US) | 1997-12-31 | — | — | WO | disclosed |
| WO-1997049393-A1 | USE OF A TACHYKININ ANTAGONIST FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF EMESIS | WARNER-LAMBERT COMPANY (US) | 1997-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232787-A1 | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic | EDNRA, EDNRB, ECE1 | TACR1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.