Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 18/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | PREP | P48147 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL664946 | 1.00 | DPP4 (0.50) | DPP4PDE10ADPP8DPP7PREP | |
| SCHEMBL5661804 | 0.86 | DPP4 (0.55) | DPP4DPP8DPP7PREP | |
| SCHEMBL666205 | 0.86 | DPP4 (0.55) | DPP4DPP8DPP7PREP | |
| SCHEMBL665215 | 0.86 | DPP4 (0.66) | DPP4DPP8DPP7PREP | |
| SCHEMBL4594687 | 0.86 | DPP4 (0.66) | DPP4DPP8DPP7PREP | |
| SCHEMBL665351 | 0.85 | DPP4 (0.52) | DPP4DPP8DPP7 | |
| SCHEMBL1436377 | 0.85 | DPP4 (0.52) | DPP4DPP8DPP7 | |
| SCHEMBL4592971 | 0.79 | DPP4 (0.63) | DPP4DPP8DPP7 | |
| SCHEMBL664047 | 0.79 | DPP4 (0.63) | DPP4DPP8DPP7 | |
| SCHEMBL665641 | 0.74 | DPP4 (0.56) | DPP4DPP8DPP7PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441719-A1 | N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003037327-A1 | N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | F. HOFFMANN-LA-ROCHE AG (CH) | 2003-05-08 | — | — | WO | disclosed |