Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.83 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.61 |
| ▸ | IGF1R | P08069 | 1/20 | 0.60 |
| ▸ | CDK1 | P06493 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656905 | 0.91 | SYK (1.00) | SYKMAPK8IGF1RCDK1GSK3B | |
| SCHEMBL3275303 | 0.90 | SYK (0.92) | SYKMAPK8IGF1RCDK1GSK3B | |
| SCHEMBL6826392 | 0.87 | AURKA (0.67) | SYKIGF1RCDK1GSK3BAURKA | |
| SCHEMBL6016622 | 0.83 | SYK (0.64) | SYKMAPK8 | |
| SCHEMBL656786 | 0.83 | SYK (0.64) | SYKMAPK8AURKA | |
| SCHEMBL14367832 | 0.82 | SYK (0.72) | SYKMAPK8IGF1RCDK1GSK3B | |
| SCHEMBL653987 | 0.81 | SYK (0.74) | SYKMAPK8IGF1RCDK1 | |
| R-112 SCHEMBL29360016 | 0.80 | SYK (1.00) | SYKMAPK8AURKA | |
| R-112 SCHEMBL655935 | 0.80 | SYK (1.00) | SYKMAPK8AURKA | |
| R-112 SCHEMBL31294216 | 0.80 | SYK (1.00) | SYKMAPK8AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004046118-A2 | 2-4-(DI-PHENYL-AMINO)-PYRIMIDINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-06-03 | — | — | WO | disclosed |