Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14598738 | 0.95 | MEN1 (0.52) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL14598638 | 0.89 | MAPT (0.54) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL14598654 | 0.88 | MEN1 (0.48) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL14628692 | 0.83 | MEN1 (0.42) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL14598649 | 0.81 | MEN1 (0.49) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL13671300 | 0.81 | MAPT (0.48) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL4931103 | 0.81 | MEN1 (0.50) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL14598650 | 0.79 | MEN1 (0.47) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL5511376 | 0.79 | MEN1 (0.47) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL5511379 | 0.79 | MEN1 (0.47) | MEN1KMT2AMAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160886-B2 | Acylated piperazine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2007-01-09 | — | — | US | disclosed |
| US-7160886-B2 | Acylated piperazine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2007-01-09 | — | — | US | disclosed |
| WO-2004078717-A1 | ACYLATED PIPERAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2004-09-16 | — | — | WO | disclosed |