Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 6/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.49 |
| ▸ | NR2E1 | Q9Y466 | 5/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.45 |
| ▸ | HTR2B | P41595 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9654112 | 0.92 | HTR1B (0.47) | HTR1BSLC6A4SLC6A2NR2E1CYP1A2 | |
| SCHEMBL10768376 | 0.91 | KCNA3 (0.49) | HTR1BSLC6A4SLC6A2NR2E1CYP1A2 | |
| SCHEMBL4982131 | 0.87 | CYP1A2 (0.56) | HTR1BSLC6A4SLC6A2NR2E1CYP1A2 | |
| SCHEMBL4056612 | 0.85 | NR2E1 (0.48) | HTR1BSLC6A4SLC6A2NR2E1CYP1A2 | |
| SCHEMBL7214604 | 0.84 | CYP1A2 (0.46) | HTR1BSLC6A4SLC6A2NR2E1CYP1A2 | |
| SCHEMBL6712567 | 0.84 | KDM4E (0.44) | HTR1BSLC6A4SLC6A2NR2E1CYP1A2 | |
| SCHEMBL11784563 | 0.84 | HTR1B (0.45) | HTR1BSLC6A4SLC6A2NR2E1CYP1A2 | |
| SCHEMBL23067897 | 0.83 | HTR1B (0.47) | HTR1BSLC6A4SLC6A2NR2E1CYP1A2 | |
| SCHEMBL6301620 | 0.83 | HTR1B (0.47) | HTR1BSLC6A4SLC6A2NR2E1CYP1A2 | |
| SCHEMBL8344333 | 0.83 | MCHR1 (0.51) | HTR1BSLC6A4SLC6A2NR2E1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040106808-A1 | Processes for preparing calanolide a and intermediates thereof | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 2004-06-03 | — | — | US | disclosed |
| EP-1352907-A1 | PROCESSES FOR PREPARING CALANOLIDE A AND INTERMEDIATES THEREOF | KURARAY CO., LTD. (JP) | 2003-10-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106808-A1 | Processes for preparing calanolide a and intermediates thereof | CALR, CYP51A1, CYP4A11 | HTR1B 4154/4885SLC6A4 4526/4885SLC6A2 4702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.