Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 17/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.54 |
| ▸ | PRKACA | P17612 | 6/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.54 |
| ▸ | PIM1 | P11309 | 5/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.54 |
| ▸ | PKN2 | Q16513 | 5/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.54 |
| ▸ | STK17A | Q9UEE5 | 5/20 | 0.54 |
| ▸ | CLK2 | P49760 | 4/20 | 0.54 |
| ▸ | PRKG1 | Q13976 | 4/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.54 |
| ▸ | PRKX | P51817 | 3/20 | 0.54 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.52 |
| ▸ | CHUK | O15111 | 2/20 | 0.52 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6833456 | 0.82 | AKT1 (0.53) | AKT1CLK4ROCK2PRKACAROCK1 | |
| Trifluoroacetic Acid SCHEMBL6833640 | 0.79 | MAOB (0.52) | AKT1CLK4ROCK2PRKACAROCK1 | |
| Trifluoroacetic Acid SCHEMBL6927112 | 0.78 | AKT1 (0.54) | AKT1CLK4ROCK2PRKACAROCK1 | |
| Trifluoroacetic Acid SCHEMBL6927108 | 0.78 | AKT1 (0.54) | AKT1CLK4ROCK2PRKACAROCK1 | |
| SCHEMBL7691611 | 0.78 | AKT1 (0.59) | AKT1CLK4ROCK2PRKACAROCK1 | |
| SCHEMBL7691608 | 0.78 | AKT1 (0.59) | AKT1CLK4ROCK2PRKACAROCK1 | |
| Trifluoroacetic Acid SCHEMBL6855759 | 0.77 | AKT1 (0.46) | AKT1CLK4ROCK2PRKACAROCK1 | |
| Trifluoroacetic Acid SCHEMBL6834235 | 0.71 | AKT1 (0.84) | AKT1CLK4ROCK2PRKACAROCK1 | |
| Hydrochloric Acid SCHEMBL6833010 | 0.70 | AKT1 (0.97) | AKT1CLK4ROCK2PRKACAROCK1 | |
| SCHEMBL6855179 | 0.70 | AKT1 (1.00) | AKT1CLK4ROCK2PRKACAROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463505-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2004-10-06 | — | — | EP | claimed |
| WO-2003051366-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ABBOTT LABORATORIES (US) | 2003-06-26 | — | — | WO | claimed |