Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 12/20 | 0.59 |
| ▸ | SRC | P12931 | 7/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.54 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3228926 | 0.95 | SRC (0.61) | MAP2K1SRCIKBKBEGFRLYN | |
| SCHEMBL3227985 | 0.89 | SRC (0.61) | MAP2K1SRCIKBKBEGFRLYN | |
| SCHEMBL3232734 | 0.88 | SRC (0.62) | MAP2K1SRCIKBKBEGFRLYN | |
| SCHEMBL3228605 | 0.87 | SRC (0.65) | MAP2K1SRCIKBKBEGFRLYN | |
| SCHEMBL5253249 | 0.87 | SRC (0.64) | MAP2K1SRCIKBKBEGFRLYN | |
| SCHEMBL3227823 | 0.86 | SRC (0.64) | MAP2K1SRCIKBKBEGFRLYN | |
| SCHEMBL3223808 | 0.86 | SRC (0.56) | MAP2K1SRCIKBKBEGFRLYN | |
| SCHEMBL3228240 | 0.85 | SRC (0.60) | MAP2K1SRCEGFRKDRFYN | |
| SCHEMBL3232113 | 0.84 | SRC (0.53) | MAP2K1SRCEGFRKDRFYN | |
| SCHEMBL3230525 | 0.82 | SRC (0.52) | MAP2K1SRCEGFRKDRFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689772-B1 | ANTINEOPLASTIC AGENTS; OSTEOPOROSIS; POLYCYSTIC KIDNEY DISEASE; ANTIVIRAL AGENTS | WYETH | 2004-02-10 | — | — | US | disclosed |