Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 7/20 | 0.67 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | STS | P08842 | 4/20 | 0.54 |
| ▸ | THRA | P10827 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 3/20 | 0.50 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.50 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9506499 | 1.00 | HSD17B3 (0.67) | HSD17B3HTR7STSTHRATHRB | |
| SCHEMBL3844202 | 1.00 | HSD17B3 (0.67) | HSD17B3HTR7STSTHRATHRB | |
| SCHEMBL3027932 | 0.98 | HSD17B3 (0.66) | HSD17B3HTR7STSTHRATHRB | |
| SCHEMBL6579608 | 0.93 | HSD17B3 (0.65) | HSD17B3HTR7STSL3MBTL1 | |
| SCHEMBL2903307 | 0.92 | HSD17B3 (0.58) | HSD17B3LMNAMAPT | |
| SCHEMBL13085794 | 0.87 | HSD17B3 (0.85) | HSD17B3HTR7STSTHRATHRB | |
| SCHEMBL13085847 | 0.87 | HSD17B3 (0.85) | HSD17B3HTR7STSTHRATHRB | |
| SCHEMBL5213534 | 0.86 | HSD17B3 (0.51) | HSD17B3STSL3MBTL1LMNAMAPT | |
| SCHEMBL6579588 | 0.85 | HSD17B3 (0.62) | HSD17B3HTR7STSL3MBTL1 | |
| SCHEMBL18753070 | 0.85 | HSD17B3 (0.84) | HSD17B3HTR7STSTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575964-B1 | N-(BENZYL)AMINOALKYL CARBOXYLATE, PHOSPHINATES, PHOSPHONATES AND TETRAZOLES AS EDG RECEPTOR AGONISTS | MERCK & CO INC (US) | 2009-11-11 | — | — | EP | disclosed |
| US-7351725-B2 | N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as Edg receptor agonists | MERCK & CO., INC. (US) | 2008-04-01 | — | — | US | disclosed |
| US-7351725-B2 | N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as Edg receptor agonists | MERCK & CO., INC. (US) | 2008-04-01 | — | — | US | disclosed |
| US-20040058894-A1 | Selective S1P1/Edg1 receptor agonists | DOHERTY GEORGE A (US) | 2004-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058894-A1 | Selective S1P1/Edg1 receptor agonists | S1PR1, S1PR3, S1PR2 | HSD17B3 1012/4885HTR7 1369/4885STS 4015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.