Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.58 |
| ▸ | FAAH | O00519 | 6/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5580108 | 1.00 | CCR3 (0.58) | CCR3FAAHTP53NPC1RAB9A | |
| SCHEMBL3928596 | 1.00 | CCR3 (0.58) | CCR3FAAHTP53NPC1RAB9A | |
| SCHEMBL5741649 | 0.88 | CCR3 (0.61) | CCR3MEN1KMT2A | |
| SCHEMBL5741643 | 0.88 | CCR3 (0.61) | CCR3MEN1KMT2A | |
| SCHEMBL5854789 | 0.88 | CCR3 (0.61) | CCR3MEN1KMT2A | |
| SCHEMBL5742782 | 0.85 | CCR3 (0.52) | CCR3FAAHRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL5742772 | 0.85 | CCR3 (0.52) | CCR3FAAHRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL5741336 | 0.85 | CCR3 (0.56) | CCR3FAAHTP53NPC1RAB9A | |
| SCHEMBL5741334 | 0.85 | CCR3 (0.56) | CCR3FAAHTP53NPC1RAB9A | |
| SCHEMBL4034536 | 0.80 | MCHR1 (0.65) | CCR3NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770650-B2 | CHEMOKINE RECEPTOR (CCR) ANTAGONISTS SUCH AS N-(1(S)-(4-(3,4-DICHLOROBENZYL)PIPERAZIN-1-YLMETHYL)-2-METHYLPROPYL)-4 -METHYLBENZAMIDE DIHYDROCHLORIDE SALT FOR TREATMENT OF ASTHMA | SYNTEX (U.S.A.) LLC | 2004-08-03 | — | — | US | disclosed |