Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.49 |
| ▸ | DNMT1 | P26358 | 4/20 | 0.48 |
| ▸ | DNMT3A | Q9Y6K1 | 3/20 | 0.48 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.48 |
| ▸ | ASF1A | Q9Y294 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | BCR | P11274 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | PIR | O00625 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CLK3 | P49761 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL678878 | 0.97 | KDR (0.52) | KDREGFRMCHR1DNMT1DNMT3A | |
| SCHEMBL684431 | 0.92 | KDR (0.48) | KDREGFRDNMT1DNMT3ADNMT3L | |
| SCHEMBL678873 | 0.90 | KDR (0.50) | KDREGFRDNMT1DNMT3ADNMT3L | |
| SCHEMBL683734 | 0.88 | EGFR (0.52) | KDREGFRDNMT1DNMT3ADNMT3L | |
| SCHEMBL678913 | 0.85 | KDR (0.55) | KDREGFRABL1BCRHDAC1 | |
| SCHEMBL683733 | 0.83 | DNMT1 (0.50) | KDRMCHR1DNMT1DNMT3ADNMT3L | |
| SCHEMBL683853 | 0.82 | DNMT1 (0.49) | KDREGFRMCHR1DNMT1DNMT3A | |
| SCHEMBL682916 | 0.76 | DNMT1 (0.60) | DNMT1DNMT3ADNMT3LHDAC1 | |
| SCHEMBL678697 | 0.73 | DNMT1 (0.58) | DNMT1DNMT3ADNMT3LHDAC1 | |
| SCHEMBL682918 | 0.71 | MCHR1 (0.49) | MCHR1DNMT1DNMT3ADNMT3L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269758-A1 | NAPHTHYRIDINONES AS PROTEIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2011-11-03 | — | — | US | disclosed |
| WO-2010002779-A2 | NAPHTHYRIDININONES AS AURORA KINASE INHIBITORS | MERCK SERONO S.A. (CH) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269758-A1 | NAPHTHYRIDINONES AS PROTEIN KINASE INHIBITORS | AURKA, AURKC, AURKB | KDR 2896/4885EGFR 1241/4885MCHR1 4277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.