Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6842647 | 0.99 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DMET | |
| SCHEMBL6654798 | 0.95 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DMET | |
| SCHEMBL6841905 | 0.95 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DMET | |
| SCHEMBL6661025 | 0.94 | PDE4D (0.49) | PDE4APDE4BPDE4CPDE4DMET | |
| SCHEMBL6837244 | 0.93 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DMET | |
| SCHEMBL6657923 | 0.92 | PDE4B (0.52) | PDE4APDE4BPDE4CPDE4DMET | |
| SCHEMBL6654582 | 0.92 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DMET | |
| SCHEMBL6842477 | 0.91 | PDE4B (0.52) | PDE4APDE4BPDE4CPDE4DMET | |
| SCHEMBL27611103 | 0.91 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DMET | |
| SCHEMBL7801593 | 0.91 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040235845-A1 | Use of phosphodiesterase iv inhibitors | MERCK PATENT GESSELSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235845-A1 | Use of phosphodiesterase iv inhibitors | PDE4A, PDE3A, PDE3B | PDE4A 1/4885PDE4B 4/4885PDE4C 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.