Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.57 |
| ▸ | PIM1 | P11309 | 2/20 | 0.57 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 17/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | FLT4 | P35916 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.54 |
| ▸ | DHODH | Q02127 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6807413 | 0.75 | AURKB (0.62) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6805542 | 0.75 | AURKB (0.61) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6811018 | 0.75 | AURKB (0.61) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6806566 | 0.73 | AURKB (1.00) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL7162295 | 0.72 | PIM1 (0.69) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL25022851 | 0.71 | PARP1 (0.63) | AURKBPIM1PIM3MKNK2BRSK1 | |
| SCHEMBL7135390 | 0.71 | PARP1 (0.81) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6805709 | 0.71 | AURKB (0.69) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6805047 | 0.71 | AURKB (0.72) | AURKBPIM1PIM3MKNK2FLT3 | |
| SCHEMBL6811029 | 0.71 | AURKB (0.72) | AURKBPIM1PIM3MKNK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040034078-A1 | Benzimidazole inhibitors of poly(ADP-ribosyl) polymerase | AGOURON PHARMACEUTICALS, INC. | 2004-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034078-A1 | Benzimidazole inhibitors of poly(ADP-ribosyl) polymerase | PARP1, PARP11, PARP2 | AURKB 549/4885PIM1 909/4885PIM3 1318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.