Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 13/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 15/20 | 0.53 |
| ▸ | SRC | P12931 | 14/20 | 0.52 |
| ▸ | SYK | P43405 | 14/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6842565 | 0.92 | SRC (0.63) | GSK3AMAPK14SRCSYK | |
| SCHEMBL6840054 | 0.86 | MAPK14 (0.54) | GSK3AMAPK14SRCSYK | |
| SCHEMBL6546610 | 0.86 | MAPK14 (0.55) | GSK3AMAPK14SRCSYK | |
| SCHEMBL6546532 | 0.84 | MAPK14 (0.52) | GSK3AMAPK14SRCSYK | |
| SCHEMBL6546703 | 0.84 | GSK3A (0.54) | GSK3AMAPK14SRCSYK | |
| SCHEMBL6546009 | 0.83 | MAPK14 (0.55) | GSK3AMAPK14SRCSYK | |
| SCHEMBL6546905 | 0.83 | MAPK14 (0.55) | GSK3AMAPK14SRCSYK | |
| SCHEMBL6546838 | 0.82 | MAPK14 (0.53) | GSK3AMAPK14SRCSYK | |
| SCHEMBL6546731 | 0.82 | MAPK14 (0.51) | GSK3AMAPK14SRCSYK | |
| SCHEMBL6546930 | 0.81 | MAPK14 (0.63) | GSK3AMAPK14SRCSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6765009-B2 | N-(5-TERT-BUTYL-3-(3-(4-((2-DIMETHYLAMINOMETHYL-PYRIDIN-4-YL) -PIPERAZIN-1-YL-METHYL) NAPHTHALEN-1-YL)UREIDO)-2-METHOXYPHENYL) METHANESULFONAMIDE FOR EXAMPLE; CYTOKINE INHIBITORS FOR TREATMENT OF INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-07-20 | — | — | US | disclosed |