Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.85 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.85 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.85 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.85 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.79 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.79 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.79 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.79 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.79 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.79 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.79 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.79 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.79 |
| ▸ | NAMPT | P43490 | 2/20 | 0.68 |
| ▸ | MMP1 | P03956 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6842697 | 1.00 | HDAC1 (0.85) | HDAC1HDAC2HDAC3NCOR2HDAC4 | |
| SCHEMBL4476526 | 0.92 | HDAC1 (1.00) | HDAC1HDAC2HDAC3NCOR2HDAC4 | |
| SCHEMBL4476529 | 0.92 | HDAC1 (1.00) | HDAC1HDAC2HDAC3NCOR2HDAC4 | |
| SCHEMBL30267913 | 0.89 | HDAC1 (1.00) | HDAC1HDAC2HDAC3NCOR2HDAC4 | |
| SCHEMBL8057949 | 0.89 | HDAC1 (1.00) | HDAC1HDAC2HDAC3NCOR2HDAC4 | |
| SCHEMBL5500152 | 0.89 | HDAC1 (1.00) | HDAC1HDAC2HDAC3NCOR2HDAC4 | |
| SCHEMBL28456829 | 0.86 | HDAC1 (0.71) | HDAC1HDAC2HDAC3NCOR2HDAC4 | |
| Tucidinostat SCHEMBL4483082 | 0.81 | HDAC1 (1.00) | HDAC1HDAC2HDAC3NCOR2HDAC4 | |
| Tucidinostat SCHEMBL29350211 | 0.81 | HDAC1 (1.00) | HDAC1HDAC2HDAC3NCOR2HDAC4 | |
| Tucidinostat SCHEMBL29813059 | 0.81 | HDAC1 (1.00) | HDAC1HDAC2HDAC3NCOR2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2860174-A2 | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation acivity | Shenzhen Chipscreen Biosciences Ltd. (CN) | 2015-04-15 | — | — | EP | disclosed |
| US-20040224991-A1 | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224991-A1 | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity | HDAC1, HDAC5, HDAC11 | HDAC1 1/4885HDAC2 7/4885HDAC3 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.