Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.59 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.59 |
| ▸ | DPP4 | P27487 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.59 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.59 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.59 |
| ▸ | GAPDH | P04406 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | STAT6 | P42226 | 1/20 | 0.59 |
| ▸ | PI4KA | P42356 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.59 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.59 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.59 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25284573 | 0.95 | ADORA1 (0.66) | ADORA1ADORA2AADORA2BSLC29A1ADORA3 | |
| SCHEMBL24968581 | 0.95 | ADORA1 (0.66) | ADORA1ADORA2AADORA2BSLC29A1ADORA3 | |
| SCHEMBL4456275 | 0.95 | ADORA1 (0.66) | ADORA1ADORA2AADORA2BSLC29A1ADORA3 | |
| SCHEMBL24872346 | 0.95 | ADORA1 (0.66) | ADORA1ADORA2AADORA2BSLC29A1ADORA3 | |
| SCHEMBL4456272 | 0.95 | ADORA1 (0.66) | ADORA1ADORA2AADORA2BSLC29A1ADORA3 | |
| SCHEMBL25284572 | 0.95 | ADORA1 (0.66) | ADORA1ADORA2AADORA2BSLC29A1ADORA3 | |
| SCHEMBL30605195 | 0.95 | ADORA1 (0.66) | ADORA1ADORA2AADORA2BSLC29A1ADORA3 | |
| SCHEMBL8007481 | 0.94 | ADORA2A (0.67) | ADORA1ADORA2AADORA2BSLC29A1ADORA3 | |
| SCHEMBL8007474 | 0.94 | ADORA2A (0.67) | ADORA1ADORA2AADORA2BSLC29A1ADORA3 | |
| SCHEMBL6261501 | 0.94 | ADORA2A (0.67) | ADORA1ADORA2AADORA2BSLC29A1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6762169-B1 | IMPROVED TRANSMEMBRANE DELIVERY OF NUCLEOSIDES CONJUGATED TO AN ARYLPROPIONIC ACID LIGAND (IBUPROFEN) WHICH HAS AFFINITY FOR PLASMA PROTEIN ALBUMIN; ANTISENSE THERAPY | ISIS PHARMACEUTICALS, INC. | 2004-07-13 | — | — | US | disclosed |
| US-6656730-B1 | Attached to an arylpropionic acid that interacts with human serum albumin; acid is ibuprofen, suprofen, ketoprofen, (S)-(+)- pranoprofen, or carprofen. | ISIS PHARMACEUTICALS, INC. | 2003-12-02 | — | — | US | disclosed |
| EP-1185305-A1 | LIGAND-CONJUGATED OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076554-A1 | LIGAND-CONJUGATED OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 2000-12-21 | — | — | WO | disclosed |