Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.79 |
| ▸ | MAP2K2 | P36507 | 16/20 | 0.79 |
| ▸ | RAF1 | P04049 | 1/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.64 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.64 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.64 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.64 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.64 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.64 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.64 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zapnometinib SCHEMBL30298104 | 0.88 | MAP2K1 (1.00) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| Zapnometinib SCHEMBL29362260 | 0.88 | MAP2K1 (1.00) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| Zapnometinib SCHEMBL1488782 | 0.88 | MAP2K1 (1.00) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL29425375 | 0.88 | MAP2K1 (1.00) | MAP2K1MAP2K2PIM1CAMK2BBRAF | |
| SCHEMBL3762426 | 0.88 | MAP2K1 (1.00) | MAP2K1MAP2K2PIM1CAMK2BBRAF | |
| SCHEMBL5396229 | 0.86 | MAP2K1 (0.77) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL29781350 | 0.85 | MAP2K1 (0.76) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL5677719 | 0.85 | MAP2K1 (0.79) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL4856920 | 0.82 | MAP2K1 (0.71) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL4861211 | 0.81 | MAP2K1 (0.82) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150527-B1 | ANTHRANILIC ACID DERIVATIVE AS ANTICANCER AGENT AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2011-01-19 | — | — | EP | disclosed |
| WO-2008114275-A2 | ANTHRANILIC ACID DERIVATIVES AS ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2008-09-25 | — | — | WO | disclosed |
| US-20040122058-A1 | Use of specific compounds particularly kinase inhibitors for treating viral infections | AXXIMA PHARMACEUTICALS AG (DE) | 2004-06-24 | — | — | US | disclosed |