Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK2 | Q9NYY3 | 18/20 | 0.38 |
| ▸ | PLK1 | P53350 | 16/20 | 0.38 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6844537 | 1.00 | PLK2 (0.38) | PLK2PLK1PLK3DPP4 | |
| SCHEMBL2048004 | 0.85 | PLK2 (0.50) | PLK2PLK1PLK3 | |
| SCHEMBL12392654 | 0.85 | PLK2 (0.50) | PLK2PLK1PLK3 | |
| SCHEMBL2048528 | 0.85 | PLK2 (0.50) | PLK2PLK1PLK3 | |
| SCHEMBL6844619 | 0.84 | PLK2 (0.41) | PLK2PLK1PLK3 | |
| SCHEMBL2690239 | 0.81 | PLK2 (0.37) | PLK2PLK1PLK3 | |
| SCHEMBL1688643 | 0.81 | PLK2 (0.37) | PLK2PLK1PLK3 | |
| SCHEMBL6844378 | 0.81 | PLK2 (0.40) | PLK2PLK1PLK3 | |
| SCHEMBL2688460 | 0.80 | PLK2 (0.37) | PLK2PLK1PLK3 | |
| SCHEMBL2689330 | 0.80 | PLK2 (0.37) | PLK2PLK1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |