Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 7/20 | 0.52 |
| ▸ | PLK2 | Q9NYY3 | 7/20 | 0.52 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2052780 | 0.86 | PLK2 (0.72) | PLK1PLK2PLK3PIK3CD | |
| SCHEMBL6844641 | 0.84 | PLK1 (0.73) | PLK1PLK2PLK3 | |
| SCHEMBL2688044 | 0.81 | PLK1 (0.52) | PLK1PLK2PLK3ADORA2AADORA1 | |
| SCHEMBL2689987 | 0.81 | PLK1 (0.52) | PLK1PLK2PLK3 | |
| SCHEMBL2049848 | 0.77 | PLK2 (0.75) | PLK1PLK2PLK3 | |
| SCHEMBL1288492 | 0.73 | PLK1 (0.54) | PLK1PLK2PLK3 | |
| SCHEMBL2689343 | 0.73 | PLK1 (0.54) | PLK1PLK2PLK3 | |
| SCHEMBL2047202 | 0.71 | PLK2 (0.75) | PLK1PLK2PLK3 | |
| SCHEMBL2047203 | 0.71 | PLK2 (0.75) | PLK1PLK2PLK3 | |
| SCHEMBL2048799 | 0.71 | PLK2 (0.75) | PLK1PLK2PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |