Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 5/20 | 0.47 |
| ▸ | PLK2 | Q9NYY3 | 5/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | MTOR | P42345 | 3/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 2/20 | 0.30 |
| ▸ | SYK | P43405 | 2/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6844759 | 0.86 | PLK1 (0.47) | PLK1PLK2PRKDCPIK3CAMTOR | |
| SCHEMBL6844686 | 0.83 | PLK1 (0.61) | PLK1PLK2PRKDCPIK3CAMTOR | |
| SCHEMBL6844827 | 0.78 | PLK1 (0.60) | PLK1PLK2PRKDCPIK3CAMTOR | |
| SCHEMBL2053089 | 0.77 | PLK2 (0.74) | PLK1PLK2PLK3 | |
| SCHEMBL12277116 | 0.77 | PLK2 (0.74) | PLK1PLK2PLK3 | |
| SCHEMBL1288407 | 0.71 | PLK1 (0.55) | PLK1PLK2PRKDCPLK3 | |
| SCHEMBL2688357 | 0.71 | PLK1 (0.55) | PLK1PLK2PRKDCPLK3 | |
| SCHEMBL1288404 | 0.71 | PLK1 (0.55) | PLK1PLK2PRKDCPLK3 | |
| SCHEMBL5931430 | 0.71 | PLK1 (0.55) | PLK1PLK2PRKDCPLK3 | |
| SCHEMBL2688346 | 0.71 | PLK1 (0.55) | PLK1PLK2PRKDCPLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079114-A1 | PTERIDINONES AS INHIBITORS OF POLO - LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |