Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK2 | Q9NYY3 | 20/20 | 0.70 |
| ▸ | PLK1 | P53350 | 19/20 | 0.70 |
| ▸ | PLK3 | Q9H4B4 | 10/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2052264 | 0.87 | PLK2 (0.77) | PLK2PLK1PLK3 | |
| SCHEMBL2052267 | 0.87 | PLK2 (0.77) | PLK2PLK1PLK3 | |
| SCHEMBL2340233 | 0.87 | PLK2 (0.75) | PLK2PLK1PLK3 | |
| SCHEMBL2340228 | 0.87 | PLK2 (0.75) | PLK2PLK1PLK3 | |
| SCHEMBL2051913 | 0.87 | PLK2 (0.73) | PLK2PLK1PLK3 | |
| SCHEMBL2053368 | 0.87 | PLK2 (0.73) | PLK2PLK1PLK3 | |
| SCHEMBL2051910 | 0.87 | PLK2 (0.73) | PLK2PLK1PLK3 | |
| SCHEMBL2053370 | 0.87 | PLK2 (0.73) | PLK2PLK1PLK3 | |
| SCHEMBL2052722 | 0.86 | PLK2 (0.69) | PLK2PLK1PLK3 | |
| SCHEMBL2052724 | 0.86 | PLK2 (0.69) | PLK2PLK1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |