Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1992629 | 0.86 | BACE1 (0.51) | BACE1CTSD | |
| SCHEMBL15509564 | 0.86 | BACE1 (0.51) | BACE1CTSD | |
| SCHEMBL15509780 | 0.86 | BACE1 (0.51) | BACE1CTSD | |
| SCHEMBL6845261 | 0.79 | BACE1 (0.47) | BACE1CTSD | |
| SCHEMBL6845256 | 0.79 | BACE1 (0.47) | BACE1CTSD | |
| SCHEMBL15494508 | 0.79 | BACE1 (0.47) | BACE1CTSD | |
| SCHEMBL6845263 | 0.79 | BACE1 (0.47) | BACE1CTSD | |
| SCHEMBL1993062 | 0.79 | BACE1 (0.61) | BACE1CTSD | |
| SCHEMBL15510401 | 0.79 | BACE1 (0.61) | BACE1CTSD | |
| SCHEMBL15510125 | 0.76 | BACE1 (0.68) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |
| WO-2010030954-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-03-18 | — | — | WO | disclosed |