Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.75 |
| ▸ | CTSD | P07339 | 3/20 | 0.74 |
| ▸ | CTSE | P14091 | 1/20 | 0.74 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7924893 | 0.92 | BACE1 (0.85) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL1992842 | 0.90 | BACE1 (0.77) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL15510542 | 0.90 | BACE1 (0.77) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL1992843 | 0.90 | BACE1 (0.77) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL1994399 | 0.89 | BACE1 (0.72) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL1995584 | 0.89 | BACE1 (0.72) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL1995700 | 0.89 | BACE1 (0.72) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL2000524 | 0.88 | BACE1 (0.70) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL2000522 | 0.88 | BACE1 (0.70) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL15509997 | 0.88 | BACE1 (0.70) | BACE1KCNH2CTSDCTSEBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |
| WO-2010030954-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-03-18 | — | — | WO | disclosed |