Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.75 |
| ▸ | CTSD | P07339 | 15/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2371473 | 0.95 | BACE1 (0.73) | BACE1KCNH2CTSD | |
| SCHEMBL15509968 | 0.89 | BACE1 (1.00) | BACE1KCNH2CTSD | |
| SCHEMBL2525830 | 0.89 | BACE1 (0.64) | BACE1KCNH2CTSD | |
| SCHEMBL2523399 | 0.89 | BACE1 (0.64) | BACE1KCNH2CTSD | |
| SCHEMBL15509957 | 0.85 | BACE1 (1.00) | BACE1KCNH2CTSD | |
| SCHEMBL15509665 | 0.85 | BACE1 (1.00) | BACE1KCNH2CTSD | |
| SCHEMBL12212511 | 0.85 | BACE1 (0.70) | BACE1KCNH2CTSD | |
| SCHEMBL15510654 | 0.84 | BACE1 (0.88) | BACE1KCNH2CTSD | |
| SCHEMBL15509932 | 0.83 | BACE1 (0.81) | BACE1KCNH2CTSD | |
| SCHEMBL2371103 | 0.83 | BACE1 (0.76) | BACE1KCNH2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883782-B2 | Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-8883782-B2 | Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2014-11-11 | — | — | US | disclosed |
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |