Butyric Acid

Butyric Acid

SCHEMBL6846134

CCCC(=O)O.CCO.O

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Butyric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR3 O14843 2/20 0.81
HDAC3 O15379 1/20 0.81
HDAC1 Q13547 1/20 0.81
HDAC2 Q92769 1/20 0.81
HDAC8 Q9BY41 1/20 0.81
AKR1B1 P15121 1/20 0.52
GPR84 Q9NQS5 7/20 0.50
PPARG P37231 7/20 0.50
PPARD Q03181 7/20 0.50
PPARA Q07869 7/20 0.50
HDAC11 Q96DB2 5/20 0.50
TSHR P16473 4/20 0.50
PTPN1 P18031 3/20 0.50
ALDH1A1 P00352 2/20 0.50
TLR2 O60603 2/20 0.50
TDP1 Q9NUW8 2/20 0.50
FABP4 P15090 2/20 0.50
KMT2A Q03164 2/20 0.50
SLC22A6 Q4U2R8 1/20 0.50
SLC22A8 Q8TCC7 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Butyric Acid SCHEMBL6507304 0.97 FFAR3 (0.77) FFAR3HDAC3HDAC1HDAC2HDAC8
Butyric Acid SCHEMBL5571639 0.97 FFAR3 (0.87) FFAR3HDAC3HDAC1HDAC2HDAC8
Butyric Acid SCHEMBL49424 0.97
Butyric Acid SCHEMBL2123451 0.94 FFAR3 (0.81) FFAR3HDAC3HDAC1HDAC2HDAC8
Butyric Acid SCHEMBL27662216 0.94 FFAR3 (0.81) FFAR3HDAC3HDAC1HDAC2HDAC8
Butyric Acid SCHEMBL10520334 0.94 FFAR3 (0.93) FFAR3HDAC3HDAC1HDAC2HDAC8
Butyric Acid SCHEMBL28476290 0.94 FFAR3 (0.93) FFAR3HDAC3HDAC1HDAC2HDAC8
Butyric Acid SCHEMBL1650329 0.94
Butyric Acid SCHEMBL2234517 0.94
Butyric Acid SCHEMBL2230669 0.94 FFAR3 (0.93) FFAR3HDAC3HDAC1HDAC2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10568931-B2 Pharmaceutical composition comprising ginseng extracts for prevention and treatment of ophthalmological diseases GINTONIN KU BIOTECH CO., LTD. (KR) 2020-02-25 US disclosed
EP-2780310-A1 PROCESS FOR RECOVERY OF ETHANOL FROM HYDROGENOLYSIS PROCESS Celanese International Corporation (US) 2014-09-24 EP disclosed
US-8748673-B2 Process of recovery of ethanol from hydrogenolysis process CELANESE INTERNATIONAL CORPORATION (US) 2014-06-10 US disclosed
US-8563052-B2 Method for preparing gintonin, which is a novel glycolipoproetin from panax ginseng, and gintonin, which is a novel glycolipoprotein, prepared by the method KONKUK UNIVERSITY INDUSTRIAL COOPERATION CORP. (KR) 2013-10-22 US disclosed
US-20130131398-A1 Process of Recovery of Ethanol From Hydrogenolysis Process CELANESE INTERNATIONAL CORPORATION (US) 2013-05-23 US disclosed
WO-2013074570-A1 PROCESS FOR RECOVERY OF ETHANOL FROM HYDROGENOLYSIS PROCESS CELANESE INTERNATIONAL CORPORATION (US) 2013-05-23 WO disclosed
US-20120165266-A1 METHOD FOR PREPARING GINTONIN, WHICH IS A NOVEL GLYCOLIPOPROETIN FROM PANAX GINSENG, AND GINTONIN, WHICH IS A NOVEL GLYCOLIPOPROTEIN, PREPARED BY THE METHOD KONKUK UNIVERSITY INDUSTRIAL COOPERATION CORP. (KR) 2012-06-28 US disclosed
US-6773902-B1 Method for preparing lysophosphatidylethanolamine DOOSAN CORPORATION (KR) 2004-08-10 US disclosed
US-5721115-A GENETIC ENGINEERING ANTEX BIOLOGICS, INC. (US) 1998-02-24 US disclosed
US-5679547-A COMPLEXING ANTEX BIOLOGICS FORMERLLY MICROCARB INC. (US) 1997-10-21 US disclosed
US-4539202-A SYNERGISTIC MIXTURE WITH PENICILLINS BEECHAM GROUP P.L.C. (GB) 1985-09-03 US disclosed
US-4524073-A β-Lactam compounds BEECHAM GROUP P.1.C. (GB) 1985-06-18 US disclosed
US-4444754-A SYNERGISTIC WITH PENICILLIN BEECHAM GROUP LIMITED (GB) 1984-04-24 US disclosed
EP-0101199-A1 Beta-lactam compounds BEECHAM GROUP PLC (GB) 1984-02-22 EP disclosed
EP-0021836-B1 CLAVULANIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BEECHAM GROUP PLC (GB) 1983-05-11 EP disclosed
EP-0068617-A1 Derivatives of clavulanic acid, a process for their preparation and their use BEECHAM GROUP PLC (GB) 1983-01-05 EP disclosed
US-4359473-A α-Amino deoxy clavulanic acid antibacterial agents BEECHAM GROUP LIMITED (GB) 1982-11-16 US disclosed
US-4313008-A FROM A CHLORODEOXY-D-SACCHARIDE TATE & LYLE LTD. (GB) 1982-01-26 US disclosed
US-4301168-A BACTERICIDES, BETA-LACTAMASE INHIBITORS BEECHAM GROUP LIMITED (GB) 1981-11-17 US disclosed
US-RE29224-E DIISOCYANATES, DIAMINES BAYER AKTIENGESELLSCHAFT (DT) 1977-05-17 US disclosed