Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 14/20 | 0.51 |
| ▸ | HRH1 | P35367 | 14/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6847553 | 0.93 | HRH2 (0.46) | HRH2HRH1HRH3 | |
| SCHEMBL6846594 | 0.90 | HRH2 (0.52) | HRH2HRH1HRH3 | |
| SCHEMBL6842221 | 0.89 | HRH2 (0.63) | HRH2HRH1HRH3 | |
| SCHEMBL6848755 | 0.87 | HRH2 (0.63) | HRH2HRH1 | |
| SCHEMBL6842148 | 0.87 | HRH2 (0.63) | HRH2HRH1HRH3 | |
| SCHEMBL6842344 | 0.87 | HRH2 (0.60) | HRH2HRH1HRH3 | |
| SCHEMBL6842184 | 0.87 | HRH2 (0.64) | HRH2HRH1HRH3 | |
| SCHEMBL6847272 | 0.85 | HRH2 (0.50) | HRH2HRH1HRH3HSD11B1 | |
| SCHEMBL6983618 | 0.84 | HRH2 (0.61) | HRH2HRH1HRH3 | |
| SCHEMBL6846694 | 0.84 | HRH2 (0.49) | HRH2HRH1HRH3LMNAHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467727-A1 | 1,3-DISUBSTITUTED AND 1,3,3,-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | Abbott Laboratories (US) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003059341-A1 | 1,3-DISUBSTITUTED AND 1,3,3,-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2003-07-24 | — | — | WO | disclosed |