Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 9/20 | 0.48 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27604484 | 0.85 | TNNI3K (0.44) | TNNI3KSNCAEGFRALDH1A1TSHR | |
| SCHEMBL27397516 | 0.84 | ROCK1 (0.55) | TNNI3KEGFRCCNT1CCNE1CDK2 | |
| SCHEMBL10490862 | 0.83 | SNCA (0.54) | TNNI3KSNCAALDH1A1TSHRHSD17B10 | |
| SCHEMBL9818585 | 0.81 | TNNI3K (0.52) | TNNI3KSNCAEGFRCCNT1CCNE1 | |
| SCHEMBL10341613 | 0.81 | TNNI3K (0.56) | TNNI3KSNCAEGFRCCNT1CCNE1 | |
| SCHEMBL6476221 | 0.81 | SNCA (0.49) | TNNI3KSNCAALDH1A1TSHRHSD17B10 | |
| SCHEMBL10598704 | 0.81 | SNCA (0.45) | TNNI3KSNCAEGFRALDH1A1TSHR | |
| SCHEMBL11170874 | 0.81 | TNNI3K (0.51) | TNNI3KEGFR | |
| SCHEMBL11704167 | 0.80 | TNNI3K (0.54) | TNNI3KSNCAEGFRALDH1A1TSHR | |
| SCHEMBL7684666 | 0.80 | SNCA (0.42) | SNCAALDH1A1TSHRNAPRTCCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0959975-B1 | NOVEL AFFINITY LIGANDS AND THEIR USE | NOVO NORDISK AS (DK) | 2004-12-29 | — | — | EP | claimed |
| EP-0959975-B1 | NOVEL AFFINITY LIGANDS AND THEIR USE | NOVO NORDISK AS (DK) | 2004-12-29 | — | — | EP | disclosed |
| US-6756384-B2 | TREATMENT OF DISEASES AND DISORDERS RELATED TO THE HISTAMINE H3 RECEPTOR. | NOVO NORDISK A/S (DK) | 2004-06-29 | — | — | US | disclosed |
| EP-1268484-A1 | CONDENSED IMIDAZOLES AS HISTAMINE H3 RECEPTOR LIGANDS | NOVO NORDISK A/S (DK) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001068652-A1 | CONDENSED IMIDAZOLES AS HISTAMINE H3 RECEPTOR LIGANDS | NOVO NORDISK A/S (DK) | 2001-09-20 | — | — | WO | disclosed |