Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 4/20 | 0.47 |
| ▸ | HRH1 | P35367 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6842224 | 0.82 | HRH2 (0.58) | KDM4EL3MBTL1GAAHRH2HRH1 | |
| SCHEMBL6848227 | 0.81 | KDM4E (0.46) | KDM4EL3MBTL1GAAHRH2HRH1 | |
| SCHEMBL6846632 | 0.80 | HRH2 (0.60) | KDM4EHRH2HRH1HRH3SMN1; SMN2 | |
| SCHEMBL6846776 | 0.80 | HCRTR1 (0.46) | KDM4EL3MBTL1HRH2HRH1HRH3 | |
| SCHEMBL6846813 | 0.79 | HRH2 (0.48) | KDM4EL3MBTL1GAAHRH2HRH1 | |
| SCHEMBL6847424 | 0.78 | HRH2 (0.59) | KDM4EL3MBTL1HRH2HRH1MEN1 | |
| SCHEMBL6846767 | 0.78 | HRH3 (0.45) | KDM4EL3MBTL1HRH2HRH1HRH3 | |
| SCHEMBL6847912 | 0.76 | HRH2 (0.51) | L3MBTL1HRH2HRH1HRH3MAOB | |
| SCHEMBL6847409 | 0.76 | KMT2A (0.42) | KDM4EHRH2HRH1MEN1KMT2A | |
| SCHEMBL6847794 | 0.75 | HRH2 (0.49) | HRH2HRH1HRH3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467727-A1 | 1,3-DISUBSTITUTED AND 1,3,3,-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | Abbott Laboratories (US) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003059341-A1 | 1,3-DISUBSTITUTED AND 1,3,3,-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2003-07-24 | — | — | WO | disclosed |