Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6847740 | 1.00 | MAPT (0.37) | MAPTMEN1KMT2AHTR3EHTR3B | |
| SCHEMBL6847747 | 1.00 | MAPT (0.37) | MAPTMEN1KMT2AHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL6846389 | 0.99 | MAPT (0.36) | MAPTMEN1KMT2AHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL6846388 | 0.99 | MAPT (0.36) | MAPTMEN1KMT2AHTR3EHTR3B | |
| Acetic Acid SCHEMBL7742902 | 0.95 | MEN1 (0.38) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| Acetic Acid SCHEMBL7743298 | 0.95 | MEN1 (0.38) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| Acetic Acid SCHEMBL7742906 | 0.95 | MEN1 (0.38) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6846356 | 0.83 | GRIN2D (0.44) | MAPTMEN1KMT2AHTR3EHTR3B | |
| SCHEMBL499303 | 0.83 | GRIN2D (0.44) | MAPTMEN1KMT2AHTR3EHTR3B | |
| SCHEMBL499302 | 0.83 | GRIN2D (0.44) | MAPTMEN1KMT2AHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6774263-B1 | N-(2-CHLORO-5-METHYLTHIOPHENYL)-N'-(3-METHYLSULFINYLPHENYL)-N' -METHYLGUANIDINE; NEURODEGENERATIVE DISORDER TREATMENT | CAMBRIDGE NEUROSCIENCE, INC. | 2004-08-10 | — | — | US | disclosed |
| EP-1041986-A4 | PHARMACEUTICALLY ACTIVE COMPOUND AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE INC (US) | 2001-03-21 | — | — | EP | disclosed |
| EP-1041986-A1 | PHARMACEUTICALLY ACTIVE COMPOUND AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999018962-A1 | PHARMACEUTICALLY ACTIVE COMPOUND AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-04-22 | — | — | WO | disclosed |