Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | AHR | P35869 | 3/20 | 0.47 |
| ▸ | CMA1 | P23946 | 2/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.47 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.46 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | ADK | P55263 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6741494 | 0.77 | CRBN (0.54) | KDM1AAHRCMA1CRBNPDE3B | |
| SCHEMBL29899623 | 0.77 | KDM1A (0.55) | KDM1AAHRCMA1CRBNPDE3B | |
| SCHEMBL6744849 | 0.77 | KDM1A (0.55) | KDM1AAHRCMA1CRBNPDE3B | |
| SCHEMBL29850050 | 0.76 | PDE3B (0.76) | KDM1AAHRCMA1CRBNPDE3B | |
| SCHEMBL6744175 | 0.76 | PDE3B (0.76) | KDM1AAHRCMA1CRBNPDE3B | |
| SCHEMBL6742260 | 0.75 | KDM1A (0.54) | KDM1AAHRCMA1CRBNPDE3B | |
| SCHEMBL23143575 | 0.73 | PDE3B (0.54) | KDM1AAHRCMA1CRBNPDE3B | |
| SCHEMBL23143561 | 0.73 | PDE3B (0.54) | KDM1AAHRCMA1CRBNPDE3B | |
| SCHEMBL29899581 | 0.73 | PDE3B (0.54) | KDM1AAHRCMA1CRBNPDE3B | |
| SCHEMBL23143591 | 0.73 | CMA1 (0.55) | KDM1AAHRCMA1CRBNPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |