SCHEMBL6848063

SCHEMBL6848063

[CH2]/C=C/c1ccsc1-c1cnccn1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.36
MAPK8 P45983 1/20 0.36
MAPK9 P45984 1/20 0.36
MAPK10 P53779 1/20 0.36
ADORA2A P29274 1/20 0.35
ADORA1 P30542 1/20 0.35
PIK3CD O00329 1/20 0.32
PIK3CA P42336 1/20 0.32
PIK3CB P42338 1/20 0.32
PI4KA P42356 1/20 0.32
PIK3CG P48736 1/20 0.32
PI4KB Q9UBF8 1/20 0.32
CYP2E1 P05181 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2A6 P11509 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2B6 P20813 1/20 0.31
CYP2C19 P33261 1/20 0.31
PIM2 Q9P1W9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6852692 0.82 MAPK8 (0.37) CYP1A2MAPK8MAPK9MAPK10ADORA2A
SCHEMBL6852695 0.82 MAPK8 (0.37) CYP1A2MAPK8MAPK9MAPK10ADORA2A
SCHEMBL6847827 0.81 MAPK8 (0.40) CYP1A2MAPK8MAPK9MAPK10ADORA2A
SCHEMBL6852120 0.81 MAPK8 (0.39) CYP1A2MAPK8MAPK9MAPK10ADORA2A
SCHEMBL6852125 0.81 MAPK8 (0.39) CYP1A2MAPK8MAPK9MAPK10ADORA2A
SCHEMBL6851800 0.78 ADORA2A (0.35) CYP1A2ADORA2AADORA1CYP2A6PIM2
SCHEMBL6851878 0.78 MAPK8 (0.37) CYP1A2MAPK8MAPK9MAPK10ADORA2A
SCHEMBL3716216 0.75 CYP1A2 (0.41) CYP1A2MAPK8MAPK9MAPK10ADORA2A
SCHEMBL6853895 0.73 MAPK8 (0.38) CYP1A2MAPK8MAPK9MAPK10ADORA2A
SCHEMBL6853903 0.73 MAPK8 (0.38) CYP1A2MAPK8MAPK9MAPK10ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1585775-A 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials ORTHO MCNEIL PHARM INC (US) 2005-02-23 CN disclosed
US-6825170-B2 ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING ORTHO-MCNEIL PHARMACEUTICAL, INC. 2004-11-30 US disclosed
EP-1453847-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS Ortho-Mcneil Pharmaceutical, Inc. (US) 2004-09-08 EP disclosed
WO-2003050132-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2003-06-19 WO disclosed