Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 4/20 | 0.44 |
| ▸ | CTSK | P43235 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18100127 | 0.93 | KMT2A (0.60) | MEN1GAAKMT2ATDP1EPHX1 | |
| SCHEMBL23551099 | 0.90 | MEN1 (0.51) | MEN1GAAKMT2ATDP1EPHX1 | |
| SCHEMBL3341020 | 0.85 | TDP1 (0.67) | MEN1GAAKMT2ATDP1EPHX1 | |
| SCHEMBL30387270 | 0.85 | MEN1 (0.51) | MEN1GAAKMT2ATDP1EPHX1 | |
| SCHEMBL22928986 | 0.85 | MEN1 (0.51) | MEN1GAAKMT2ATDP1EPHX1 | |
| SCHEMBL19198796 | 0.85 | MEN1 (0.54) | MEN1GAAKMT2ATDP1EPHX1 | |
| SCHEMBL18100126 | 0.85 | KMT2A (0.46) | MEN1GAAKMT2ATDP1EPHX1 | |
| SCHEMBL22151304 | 0.84 | KMT2A (0.39) | MEN1GAAKMT2ATDP1EPHX1 | |
| SCHEMBL1022916 | 0.84 | KMT2A (0.55) | MEN1GAAKMT2ATDP1EPHX1 | |
| SCHEMBL3122792 | 0.83 | MEN1 (0.53) | MEN1GAAKMT2ATDP1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2457923-B1 | STEROL DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2016-01-27 | — | — | EP | disclosed |
| US-20150119585-A1 | STEROL DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD (JP) | 2015-04-30 | — | — | US | disclosed |
| US-8952003-B2 | Sterol derivative | KYOWA HAKKO KIRIN CO., LTD (JP) | 2015-02-10 | — | — | US | disclosed |
| EP-2457923-A1 | STEROL DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011010682-A1 | STEROL DERIVATIVE | 協和発酵キリン株式会社 (JP) | 2011-01-27 | — | — | WO | disclosed |
| EP-0300189-B1 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-11-02 | — | — | EP | disclosed |
| US-5223489-A | Treatment of ypertension and heart failure | UJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5142048-A | Enzyme inhibitor; carbamoyl group-containing acids | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-08-25 | — | — | US | disclosed |
| US-4921855-A | New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-01 | — | — | US | disclosed |
| EP-0300189-A2 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-01-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150119585-A1 | STEROL DERIVATIVE | NR1H3, NR1H2, SREBF1 | MEN1 1732/4885GAA 3137/4885KMT2A 3380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.