Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 14/20 | 0.46 |
| ▸ | HTR3A | P46098 | 6/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.46 |
| ▸ | HTR3B | O95264 | 4/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6849381 | 0.92 | CHRNA7 (0.41) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6849229 | 0.87 | CHRNA7 (0.47) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6009256 | 0.85 | CHRNA7 (0.62) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6006662 | 0.85 | CHRNA7 (0.62) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| Hydrochloric Acid SCHEMBL6007070 | 0.85 | CHRNA7 (0.61) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL842663 | 0.85 | CHRNA7 (0.56) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6009130 | 0.83 | CHRNA7 (0.40) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6848402 | 0.80 | CHRNA7 (0.71) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6848542 | 0.78 | CHRNA7 (0.60) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6848481 | 0.78 | CHRNA7 (0.42) | CHRNA7HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432707-A1 | AZABICYCLIC-SUBSTITUTED FUSED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-06-30 | — | — | EP | claimed |
| WO-2003029252-A1 | AZABICYCLIC-SUBSTITUTED FUSED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2003-04-10 | — | — | WO | claimed |