Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 20/20 | 0.47 |
| ▸ | PRKCB | P05771 | 4/20 | 0.47 |
| ▸ | CDK4 | P11802 | 4/20 | 0.47 |
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 19/20 | 0.46 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.45 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.45 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.45 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.45 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6850793 | 0.92 | GSK3B (0.43) | GSK3BPRKCBCDK4CDK2PDK1 | |
| SCHEMBL6801053 | 0.87 | GSK3B (0.56) | GSK3BPRKCBCDK4CDK2PDK1 | |
| SCHEMBL6848157 | 0.87 | GSK3B (0.46) | GSK3BPRKCBCDK4CDK2PDK1 | |
| SCHEMBL6848405 | 0.86 | GSK3B (0.50) | GSK3BPRKCBCDK4CDK2PDK1 | |
| SCHEMBL6849576 | 0.86 | GSK3B (0.46) | GSK3BPRKCBCDK4CDK2PDK1 | |
| SCHEMBL6802571 | 0.79 | GSK3B (0.51) | GSK3BPRKCBCDK4CDK2PDK1 | |
| SCHEMBL6799983 | 0.76 | GSK3A (0.64) | GSK3BGSK3A | |
| SCHEMBL6803325 | 0.75 | GSK3B (0.54) | GSK3BPRKCBCDK4CDK2PDK1 | |
| SCHEMBL6801058 | 0.75 | GSK3B (0.43) | GSK3BPRKCBCDK4CDK2PDK1 | |
| SCHEMBL6806993 | 0.74 | GSK3B (0.58) | GSK3BPRKCBCDK4CDK2PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1250334-B1 | Medicaments useful for the treatment of proliferative diseases | LILLY CO ELI (US) | 2004-05-19 | — | — | EP | claimed |