SCHEMBL6849955

SCHEMBL6849955

CCC(N)CC(=O)N(C(=O)C(=O)NS(C)(=O)=O)C(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)c1cnccn1)[C@@H](C)CC

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PSMB2 P49721 9/20 0.49
PSMB10 P40306 8/20 0.49
LONP1 P36776 7/20 0.49
PSMB5 P28074 4/20 0.49
PSMB11 A5LHX3 3/20 0.49
PSMA7 O14818 3/20 0.49
PSMB1 P20618 3/20 0.49
PSMA1 P25786 3/20 0.49
PSMA2 P25787 3/20 0.49
PSMA3 P25788 3/20 0.49
PSMA4 P25789 3/20 0.49
PSMB8 P28062 3/20 0.49
PSMB9 P28065 3/20 0.49
PSMA5 P28066 3/20 0.49
PSMB4 P28070 3/20 0.49
PSMB6 P28072 3/20 0.49
PSMB3 P49720 3/20 0.49
PSMA6 P60900 3/20 0.49
PSMA8 Q8TAA3 3/20 0.49
PSMB7 Q99436 3/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6846206 0.93 LONP1 (0.47) PSMB2PSMB10LONP1PSMB5PSMB11
SCHEMBL6851772 0.92 LONP1 (0.46) PSMB2PSMB10LONP1PSMB5PSMB11
SCHEMBL6846087 0.91 LONP1 (0.53) PSMB2PSMB10LONP1PSMB5PSMB11
SCHEMBL6851616 0.91 LONP1 (0.45) PSMB2PSMB10LONP1PSMB5PSMB11
SCHEMBL6850480 0.91 LONP1 (0.45) PSMB2PSMB10LONP1PSMB5PSMB11
SCHEMBL6845964 0.91 LONP1 (0.45) PSMB2PSMB10LONP1PSMB5PSMB11
SCHEMBL6850735 0.91 LONP1 (0.45) PSMB2PSMB10LONP1PSMB5PSMB11
SCHEMBL6850294 0.90 LONP1 (0.45) PSMB2PSMB10LONP1PSMB5PSMB11
SCHEMBL6850291 0.90 LONP1 (0.44) PSMB2PSMB10LONP1PSMB5PSMB11
SCHEMBL6845588 0.89 LONP1 (0.44) PSMB2PSMB10LONP1PSMB5PSMB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6774212-B2 FOR THERAPY OF VIRAL INFECTION OR AS AN ASSAY STANDARD OR REAGENT BRISTOL-MYERS SQUIBB PHARMA COMPANY 2004-08-10 US disclosed