SCHEMBL6850669

SCHEMBL6850669

[CH2]/C(F)=C\c1ccc(-c2cccnc2)s1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 14/20 0.62
CYP3A4 P08684 8/20 0.62
CYP2C19 P33261 8/20 0.62
CYP2C9 P11712 8/20 0.62
CYP2E1 P05181 7/20 0.62
CYP2B6 P20813 6/20 0.62
CYP2D6 P10635 6/20 0.50
MKNK1 Q9BUB5 1/20 0.49
MKNK2 Q9HBH9 1/20 0.49
TOP1 P11387 1/20 0.47
PRF1 P14222 1/20 0.47
HDAC3 O15379 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6850666 1.00 CYP2A6 (0.62) CYP2A6CYP3A4CYP2C19CYP2C9CYP2E1
SCHEMBL6875963 0.84 CYP2A6 (0.57) CYP2A6CYP3A4CYP2C19CYP2C9CYP2E1
SCHEMBL6875961 0.84 CYP2A6 (0.57) CYP2A6CYP3A4CYP2C19CYP2C9CYP2E1
SCHEMBL6875958 0.84 CYP2A6 (0.57) CYP2A6CYP3A4CYP2C19CYP2C9CYP2E1
SCHEMBL6852345 0.82 PRF1 (0.43) CYP2A6CYP3A4CYP2C19CYP2C9CYP2E1
SCHEMBL6852336 0.82 PRF1 (0.43) CYP2A6CYP3A4CYP2C19CYP2C9CYP2E1
SCHEMBL6852747 0.78 CYP2E1 (0.36) CYP2A6CYP3A4CYP2C19CYP2C9CYP2E1
SCHEMBL6852754 0.78 CYP2E1 (0.36) CYP2A6CYP3A4CYP2C19CYP2C9CYP2E1
SCHEMBL6852565 0.77 DYRK1A (0.57) CYP2A6CYP3A4CYP2C19CYP2C9CYP2E1
SCHEMBL6852569 0.77 DYRK1A (0.57) CYP2A6CYP3A4CYP2C19CYP2C9CYP2E1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6825170-B2 ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING ORTHO-MCNEIL PHARMACEUTICAL, INC. 2004-11-30 US disclosed
EP-1453847-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS Ortho-Mcneil Pharmaceutical, Inc. (US) 2004-09-08 EP disclosed
WO-2003050132-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2003-06-19 WO disclosed