SCHEMBL6850843

SCHEMBL6850843

O=S(=O)(Nc1ncc(Br)nc1OCC1CC1)c1cccc(Cl)c1Cl.O=S(=O)(Nc1ncc(Br)nc1OCCCOc1ccccc1)c1cccc(Cl)c1Cl

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCR4 P51679 19/20 0.67
EDNRA P25101 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1731767 0.92 CCR4 (0.78) CCR4EDNRA
SCHEMBL1732683 0.91 CCR4 (0.70) CCR4
SCHEMBL1732386 0.89 CCR4 (0.76) CCR4EDNRA
SCHEMBL1732789 0.86 CCR4 (0.74) CCR4
SCHEMBL1733380 0.80 CCR4 (0.94) CCR4EDNRA
SCHEMBL1731719 0.80 CCR4 (0.79) CCR4
SCHEMBL1732021 0.80 CCR4 (0.90) CCR4EDNRA
SCHEMBL1732895 0.79 CCR4 (0.81) CCR4EDNRA
SCHEMBL1732592 0.79 CCR4 (0.72) CCR4EDNRA
SCHEMBL1733087 0.78 CCR4 (0.62) CCR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1467976-A1 N-PYRAZINYL-PHENYLSULPHONAMIDES AND THEIR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASES AstraZeneca AB (SE) 2004-10-20 EP claimed
WO-2003059893-A1 N-PYRAZINYL-PHENYLSULPHONAMIDES AND THEIR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASES ASTRAZENECA AB (SE) 2003-07-24 WO claimed