Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.44 |
| ▸ | HTR2A | P28223 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6483457 | 0.83 | HTR2C (0.64) | HTR2CHTR2AKDM4EMEN1TP53 | |
| SCHEMBL5636444 | 0.80 | HTR2C (0.70) | HTR2CHTR2AKDM4EMEN1TP53 | |
| SCHEMBL11748404 | 0.78 | HTR2C (0.53) | HTR2CHTR2AKDM4EMEN1TP53 | |
| Hydrochloric Acid SCHEMBL11436507 | 0.77 | HTR2C (0.52) | HTR2CHTR2AKDM4EMEN1TP53 | |
| SCHEMBL5636222 | 0.71 | HTR2C (0.82) | HTR2CHTR2AKDM4EMEN1TP53 | |
| SCHEMBL31561704 | 0.71 | HTR2C (0.82) | HTR2CHTR2AKDM4EMEN1TP53 | |
| Hydrochloric Acid SCHEMBL11441398 | 0.70 | HTR2C (0.80) | HTR2CHTR2AKDM4EMEN1TP53 | |
| SCHEMBL6850266 | 0.69 | HTR2C (0.65) | HTR2CHTR2AKDM4EMEN1TP53 | |
| SCHEMBL6847653 | 0.69 | HTR2C (0.65) | HTR2CHTR2AKDM4EMEN1TP53 | |
| Hydrochloric Acid SCHEMBL6495767 | 0.68 | HTR2C (0.64) | HTR2CHTR2AKDM4EMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173440-B1 | TETRACYCLIC AZEPINOINDOLE COMPOUNDS AS 5-HT RECEPTOR LIGANDS | UPJOHN CO (US) | 2004-09-15 | — | — | EP | claimed |