Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 18/20 | 0.92 |
| ▸ | BCL2 | P10415 | 15/20 | 0.92 |
| ▸ | BAD | Q92934 | 4/20 | 0.92 |
| ▸ | BCL2L2 | Q92843 | 2/20 | 0.92 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.92 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.92 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.92 |
| ▸ | ASPH | Q12797 | 1/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19145101 | 0.96 | BCL2L1 (0.93) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| SCHEMBL19145093 | 0.96 | BCL2L1 (0.93) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| SCHEMBL2022422 | 0.96 | BCL2L1 (0.96) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| Navitoclax SCHEMBL522847 | 0.96 | BCL2L1 (1.00) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| Navitoclax SCHEMBL10316178 | 0.96 | BCL2L1 (1.00) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| SCHEMBL19503523 | 0.96 | BCL2L1 (0.92) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| Navitoclax SCHEMBL30255921 | 0.96 | BCL2L1 (1.00) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| Navitoclax SCHEMBL15005512 | 0.96 | BCL2L1 (1.00) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| Navitoclax SCHEMBL29363785 | 0.96 | BCL2L1 (1.00) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| SCHEMBL1955207 | 0.96 | BCL2L1 (0.86) | BCL2L1BCL2BADBCL2L2BCL2L11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230287510-A1 | COMPOSITIONS, PANELS, AND METHODS FOR CHARACTERIZING CHRONIC LYMPHOCYTIC LEUKEMIA | THE BROAD INSTITUTE, INC. (US) | 2023-09-14 | — | — | US | disclosed |
| US-20180221393-A1 | CXCR4 BINDING AGENTS FOR TREATMENT OF DISEASES | KREOS CAPITAL V (EXPERT FUND) L.P. (JE) | 2018-08-09 | — | — | US | disclosed |
| US-20180133212-A1 | COMBINATION OF A BCL-2 INHIBITOR AND A BROMODOMAIN INHIBITOR FOR TREATING CANCER | GILEAD SCIENCES, INC. | 2018-05-17 | — | — | US | disclosed |
| US-20120276085-A1 | COMBINATION THERAPY OF A TYPE II ANTI-CD20 ANTIBODY WITH AN ANTI-BCL-2 ACTIVE AGENT | Hoffman-La Roche. Inc. (US) | 2012-11-01 | — | — | US | disclosed |
| US-20110287006-A1 | COMBINATION THERAPY OF A TYPE II ANTI-CD20 ANTIBODY WITH AN ANTI-BCL-2 ACTIVE AGENT | Hoffman-La Roche. Inc. (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110086025-A1 | Combination Therapy of a Type II Anti-CD20 Antibody with an Anti-BCL-2 Active Agent | Hoffman-La Roche. Inc. (US) | 2011-04-14 | — | — | US | disclosed |
| US-20090098118-A1 | COMBINATION THERAPY OF A TYPE II ANTI-CD20 ANTIBODY WITH AN ANTI-BCL-2 ACTIVE AGENT | ROCHE GLYCART AG (CH) | 2009-04-16 | — | — | US | disclosed |
| WO-2008082643-A2 | COMPANION DIAGNOSTIC ASSAYS FOR CANCER THERAPY | ABBOTT LABORATORIES (US) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180133212-A1 | COMBINATION OF A BCL-2 INHIBITOR AND A BROMODOMAIN INHIBITOR FOR TREATING CANCER | BCL2, BAK1, BRD4 | BCL2L1 6/4885BCL2 1/4885BAD 20/4885 |
| US-20110287006-A1 | COMBINATION THERAPY OF A TYPE II ANTI-CD20 ANTIBODY WITH AN ANTI-BCL-2 ACTIVE AGENT | BAK1, BCL2, BCL3 | BCL2L1 7/4885BCL2 2/4885BAD 6/4885 |
| US-20120276085-A1 | COMBINATION THERAPY OF A TYPE II ANTI-CD20 ANTIBODY WITH AN ANTI-BCL-2 ACTIVE AGENT | BAK1, BCL2, BCL3 | BCL2L1 7/4885BCL2 2/4885BAD 6/4885 |
| US-20230287510-A1 | COMPOSITIONS, PANELS, AND METHODS FOR CHARACTERIZING CHRONIC LYMPHOCYTIC LEUKEMIA | BCL9, BCL9L, BCL6B | BCL2L1 61/4885BCL2 172/4885BAD 2001/4885 |
| US-20110086025-A1 | Combination Therapy of a Type II Anti-CD20 Antibody with an Anti-BCL-2 Active Agent | BAK1, BCL2, BCL3 | BCL2L1 7/4885BCL2 2/4885BAD 6/4885 |
| US-20180221393-A1 | CXCR4 BINDING AGENTS FOR TREATMENT OF DISEASES | CXCL12, CXCR4, CXCR1 | BCL2L1 21/4885BCL2 14/4885BAD 30/4885 |
| US-20090098118-A1 | COMBINATION THERAPY OF A TYPE II ANTI-CD20 ANTIBODY WITH AN ANTI-BCL-2 ACTIVE AGENT | BAK1, BCL2, BCL3 | BCL2L1 7/4885BCL2 2/4885BAD 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.