Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 13/20 | 0.54 |
| ▸ | TACR2 | P21452 | 10/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5459898 | 0.91 | TACR2 (0.53) | TACR3TACR2KCNH2HTR7OPRM1 | |
| SCHEMBL5462467 | 0.90 | TACR3 (0.55) | TACR3TACR2KCNH2OPRM1 | |
| SCHEMBL4903021 | 0.89 | TACR3 (0.63) | TACR3TACR2ALDH1A1KCNH2OPRM1 | |
| Hydrochloric Acid SCHEMBL7683491 | 0.88 | TACR3 (0.62) | TACR3TACR2ALDH1A1KCNH2OPRM1 | |
| SCHEMBL5461424 | 0.86 | TACR2 (0.53) | TACR3TACR2ALDH1A1KCNH2OPRM1 | |
| SCHEMBL5450782 | 0.82 | TACR3 (0.51) | TACR3TACR2ALDH1A1SMN1; SMN2KCNH2 | |
| SCHEMBL6853329 | 0.81 | TACR2 (0.57) | TACR3TACR2ALDH1A1KCNH2OPRM1 | |
| SCHEMBL6853049 | 0.81 | TACR3 (0.58) | TACR3TACR2KCNH2OPRM1TSHR | |
| SCHEMBL6853022 | 0.81 | TACR3 (0.51) | TACR3TACR2KCNH2OPRM1 | |
| SCHEMBL5455427 | 0.81 | TACR2 (0.53) | TACR3TACR2KCNH2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | claimed |
| US-6780875-B2 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM S.P.A. (IT) | 2004-08-24 | — | — | US | disclosed |