Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6851883 | 1.00 | HDAC1 (0.33) | HDAC1HDAC8HDAC6PIM2ALOX5 | |
| SCHEMBL6853898 | 0.83 | HDAC1 (0.32) | HDAC1HDAC8HDAC6PIM2GRM1 | |
| SCHEMBL6853894 | 0.83 | HDAC1 (0.32) | HDAC1HDAC8HDAC6PIM2GRM1 | |
| SCHEMBL6853906 | 0.83 | HDAC1 (0.32) | HDAC1HDAC8HDAC6PIM2GRM1 | |
| SCHEMBL6851817 | 0.80 | KDM4E (0.42) | HDAC1HDAC8HDAC6GRM1 | |
| SCHEMBL6851822 | 0.80 | KDM4E (0.42) | HDAC1HDAC8HDAC6GRM1 | |
| SCHEMBL6848061 | 0.78 | PIM2 (0.33) | HDAC1HDAC8HDAC6PIM2 | |
| SCHEMBL6847824 | 0.77 | MAPT (0.38) | HDAC1HDAC8HDAC6PIM2ALOX5 | |
| SCHEMBL6852034 | 0.77 | DYRK1A (0.54) | — | |
| SCHEMBL6852038 | 0.77 | DYRK1A (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1585775-A | 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials | ORTHO MCNEIL PHARM INC (US) | 2005-02-23 | — | — | CN | disclosed |
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |